I’d be lying if I said it wasn’t one of my favourite tests to interpret. GI-MAP™ DNA Stool Analysis. Report Tour. I need to find someone who take medicare to evaluate my results. Organic acid testing is one of the best ways to test for mitochondrial dysfunction, since it measures most of the intermediates in the citric acid cycle (65, 74, 75, 76). Every organic acid has one or more conjugate bases named with the suffix –ate. A number of organic acids directly or indirectly indicate deficiencies of critical vitamins such as vitamin B12, pantothenic acid, biotin, and others. Organic acid testing (OAT) is often compared to performing an emissions test on a car. Individual organic acids can be falsely elevated by diet, medications, or other factors, so proper test prep and working with an experienced practitioner is vital. It can also be used to identify subclinical (non-symptomatic) metabolic imbalances in order to PREVENT chronic illness from developing. More recently, scientists have learned that less severe mitochondrial dysfunction plays a role in many chronic conditions, including cancer, diabetes, epilepsy, and neurodegenerative diseases like Parkinson’s, Alzheimer’s, and Huntington’s disease (69, 70, 71, 72, 73). While it might be tempting to focus on individual OAs that show abnormal results, the overall pattern of abnormalities is more important (133). After the lab receives your sample, it typically takes about 2 weeks to get your results. These small, discarded organic acid molecules are byproducts of human cellular activity, the digestion of foods, and the metabolism of gastrointestinal flora. , which is a separate test for just for microbial OAs (similar to MOAT from Great Plains). Many people with chronic illnesses and neurological disorders often excrete several abnormal organic acids in their urine. These missing or malfunctioning enzymes prevent important biochemical reactions from occurring and cause metabolites (including organic acids) to accumulate (1). News & Updates See All › Provider Spotlight: Jenny Abercrombie, ND. The quantity (and sometimes the type) of organic acids produced are unique to each individual and can be influenced by a variety of factors. Organic acids are a broad class of compounds formed during fundamental metabolic processes in the body. Infection Profile (OAT+MYCO-TOX) - Urine Test toxic non-metal chemicals & ENVIRONMENTAL POLLUTANTS. The cause of these high levels could include oral antibiotic use, high sugar diets, immune deficiencies, acquired infections, as well as genetic factors.Our Organic Acids Test also includes markers for vitamin and mineral levels, oxidative stress, neurotransmitter levels, and is the only OAT to include markers for oxalates, which are highly correlated with many chronic illnesses.If abnormalities are detected using the OAT, treatments can include supplements, such as vitamins and antioxidants, or dietary modification. Organic Acids Test (OAT) URINE SAMPLE The Organic Acids Test (OAT) offers a comprehensive metabolic snapshot of a patient’s overall health with over 70 markers. ... metabolite in urine samples of male infants, control boys, and boys with autism Control infants Control boys 2-13 years Autistic Boys 2-13 years 46. Genova Diagnostics has a test called the Organix Basic Profile that includes more than 30 different OAs. To collect your sample, you are required to urinate into a collection cup first thing in the morning, before you’ve had anything to eat or drink. The names of most organic acids contain the suffix –ic, followed by the word “acid” such as lactic acid. sporogenes, botulinum, caloritolerans, mangenoti, ghoni, bifermentans, difficile, and sordellii. Avoid arabinogalactan, echinacea, reishi mushrooms, and ribose supplements for 48 hours before collection. ENVIRO-TOX Panel - Urine Test metabolic, nutritional, and neurological disorders. The GI-MAP is the most thorough stool test on the market. It's a useful test to identify key issues in depression, anxiety and ASD. I cannot imagine the amount of research that went into this article (and your whole blog, for that matter!). Organic acids are byproducts of metabolism that provide insights on how different bodily systems are performing. OAT proponents state that high glutaric acid levels may reflect vitamin B2 deficiency. do not rule out … Histamine (International) $ 52.00. Many people with chronic illnesses and neurological … About the Organic Acid Test (OAT) The Organic Acid Test is a comprehensive assessment for a wide variety of biomarkers related to yeast (candida) and bacteria toxicity – specifically clostridia bacteria. that can be used as a follow-up to the OAT for patients who have been treated for dysbiosis. More human research is needed to better understand the links between gut microbiota, diet, urinary organic acids, and various medical conditions. It helps provide a bigger picture of mitochondrial function, nutrient deficiencies, neurotransmitter metabolism, antioxidant status, detoxification abilities, and gut health, which trained and experienced clinicians can use to dig deeper. The Organic Acids Test (OAT) offers a comprehensive metabolic snapshot with over 70 markers. I’ve been there. Other inborn errors of metabolism can also be detected by urinary organic acids, including: In the United States, all newborns are screened for these diseases, so they’re usually diagnosed quickly (15). These small, discarded organic acid molecules are byproducts of human cellular activity, the digestion of foods, and the metabolism of gastrointestinal flora. Oxidative stress occurs when there is an imbalance between free radicals and antioxidants within the body (89). Organic acids are substances in which carbon and hydrogen are always present but which may also contain the elements of oxygen, nitrogen, sulfur, and phosphorus as well. Based in Asheville and Atlanta, we provide testing services to all 50 states and around the world. Testing Services … Clinical Utility. Many times, the name of the organic acid and its conjugate base(s) are used interchangeably when discussing physiology and biochemistry, such as lactate or lactic acid. If your doctor suspects vitamin B2 (riboflavin) deficiency, they will likely order a blood or a urinary riboflavin test or erythrocyte glutathione reductase test [ 28 ]. So much good information! For more information on the Comprehensive OAT, look here. IgG Food MAP with Candida + Yeast. Some functional medicine doctors recommend a urine test called the organic acids test (OAT). However, about 50% of these disorders are not detected until later in childhood, and some aren’t diagnosed until adulthood (16). Minerals and fat-soluble vitamin status cannot be measured via organic acids. Many people with chronic illnesses and neurological disorders often excrete several abnormal organic acids. offers a more detailed evaluation, with over 40 OAs. In short, I don’t recommend this as your first go-to test for gut health—or any health—diagnosis. This article was a joint-venture, written by both Erica Julson, MS, RDN, CLT (owner/founder) and Amy Richter, MS, RDN, LD, CLT (lead writer). Biometrix Labs Urine Organic Acid Testing About Organic Acids Organic Acids are chemical compounds which are used in essential metabolic processes of the body, these metabolic processes govern how your body changes food into the energy the body needs to … Some organic acidemias may be chronic and present in the first few days of life. Types of dysbiosis (and their associated urinary organic acids typically measured) include: Elevated levels of the “general bacterial overgrowth” organic acids are not diagnostic of any particular overgrowth but can help guide further testing decisions. The main difference between the two is that the Basic Profile does not include any of the OAs that serve as markers for bacteria and fungi. They also have a variety of free webinars available on their website. HPHPA (3-(3-hydroxyphenyl)-3-hydroxypropionic acid) An abnormal phenylalanine metabolite produced by gastrointestinal bacteria of . We are licensed by CLIA, the federal agency regulating laboratories, as well as by those states requiring individual licenses in addition to CLIA. Organic acid testing (OAT) has become very popular amongst functional medicine doctors and dietitians. I haven’t heard of this testing before so I really appreciate the thorough insight! More than 50 phenotypically different organic acidemias are now known since the oldest known disease, isovaleric aci­demia, was described in 1966. When these neurotransmitters are metabolized, organic acids are produced as a byproduct. Over 1,000 different organic acids have been detected in urine since this kind of testing started. In order to communicate between neurons, the nervous system produces chemical messengers called neurotransmitters. More research is needed to understand the health implications of elevated levels of these organic acids, but it can indicate a possible issue with inflammation. Organic Acid Test URINE SAMPLE. However, we couldn’t find any research supporting this. Josh Friedman of Integrative Psychotherapy of Omaha, "The Organic Acids Test has brought new meaning to my specialized practice in women's health. Some of these bacterial byproducts from the intestine enter the blood stream and may alter the metabolism of neurotransmitters such as dopamine. Mycotoxins (MYCO-TOX) - Urine Test. Commonly Purchased Items With This Test. It provides an evaluation of intestinal yeast and bacteria. Urine amino acid testing may confirm Hartnup’s disease . Functional markers of neurotransmitter metabolism that can be measured in the urine include: Again, these results are just a starting point for further investigation. Metabolism is the sum of chemical reactions in living beings by which the body builds new molecules and breaks down molecules to eliminate waste products and produce energy. Without enough of these nutritional cofactors (or if someone has genetic mutations that affect how well their enzymes work), these chemical pathways are unable to proceed at their normal pace. Possible nutrition-related reasons for poor fatty acid metabolism include carnitine and/or riboflavin deficiency or increased need for these nutrients due to genetic variants. Succinic acid is a key intermediate of both the Kreb’s cycle and the electron transport chain that generates adenosine triphosphate (ATP), the currency for most of the body’s energy transactions. Microbial Organic Acids Test (MOAT) MycoTOX Profile (Mold Exposure) Organic Acids Test (OAT) Porphyrins Profile . C.difficile . Organic Acids Test is one of my favorite tests because of the amount of information it gives and the fact that it is a non-invasive urine test which can be done at home. The urine organic acid test (OAT) can provide valuable insight into your biochemical individuality, and combined with genomics testing can help chart a course for healing complex, chronic health problems. The resulting organic acids are used by the body to generate cellular energy and provide many of the building blocks necessary for cell function. At certain levels, organic acids in urine may be indicators … Our own membership site, The Functional Nutrition Library, currently includes in-depth notes on interpreting the neurotransmitter-related organic acids, and additional notes will be added in the future. Yay functional nutrition! I’d be lying if I said it wasn’t one of my favourite tests to interpret. Because it only requires the collection of a urine sample, OAT is quick and painless for patients. They say it can reveal the underlying cause of your symptoms. Organic Acids Test – clinically significant areas Yeast & Bacteria. An individual with neurological disorders or chronic illness will often excrete several abnormal organic acids in urine… Organic acids are substances in which carbon and hy… Coronavirus IgM Antibody $ … Urinary organic acid measurement offers a functional assessment of nutrient status. While many labs offer a variety of organic acid tests, two companies are most popular: The Organic Acids Test from Great Plains Laboratory evaluates over 70 different organic acids. These organic acids can be measured in the urine via routine screening tests. An organic acid is any compound that generates protons at the prevailing pH of human blood. As a result, organic acids begin to build up and are excreted in the urine: Our urinary organic acid profiles can give us clues as to what’s happening in our bodies, and this is the basis of organic acid testing. I love when I can identify a biochemical glitch and someone can have such a profound emotional turn around. For cars, the exhaust fumes that come out of the tailpipe are a byproduct of fuel combustion, and the composition can tell us how efficiently the engine burns fuel. The Organic Acids Test (OAT) offers a comprehensive metabolic snapshot of a patient’s overall health with over 70 markers. Learn More. The Organic Acids Test (OAT) provides an accurate evaluation of intestinal yeast and bacteria. An OAT tests a multitude of organic acids that are byproducts of daily cellular metabolism. Combine the OAT Test and Amino Acids Urine test (random sample) and save! Although some organic acidemias result in lowered blood pH, other organic acidemias are associated with organic acids that are relatively weak and do not typically cause acidosis. For example, elevated levels of the organic acid methylmalonic acid (MMA) in the urine are a well-validated indicator of vitamin B12 deficiency (17). It also evaluates oxalate toxicity, as well as mitochondria function, and various markers for … Well done. This urine-based test provides a wealth of information about the functioning of various bodily systems and can be used to identify possible nutrient deficiencies, gut dysbiosis, and more. , currently includes in-depth notes on interpreting the neurotransmitter-related organic acids, and additional notes will be added in the future. Thus, the conjugate base of lactic acid is lactate. Nutritional Neuroscience 2010 Vol 13 No 3: 1-10 47 Acute Schizophrenia . The OAT test covers intestinal yeast, fungal and bacterial levels, oxalate levels, Neurotransmitter levels, detoxification markers, vitamin requirements and mineral metabolism. It’s frustrating having no idea what you’re fixing, what’s working, … that includes more than 30 different OAs. Organic acids are most commonly analyzed in urine because they are not extensively reabsorbed in the kidney tubules after glomerular filtration. Urine. MMA then builds up in the blood and is eventually excreted in the urine, where it can be detected by an organic acid test. Omega-3 Index Complete Test. Through organic acid testing, we can detect possible nutrient deficiencies, gut dysbiosis, and other imbalances in metabolism. Anyone who suffers from a chronic health condition or who simply wants to gain insight into their overall metabolic health is likely to benefit from OAT. The Organix Comprehensive Profile offers a more detailed evaluation, with over 40 OAs. Patient should avoid apples, grapes (including raisins), pears, cranberries and their juices 48 hours prior to specimen collection. If you have additional questions regarding our licenses or quality assurance practices, please contact us. GPL-TOX - Toxic Organic Chemical Profile - Urine Test. The Microbial Organic Acids Test (MOAT) is ideal for follow-up to the OAT and is often recommended by practitioners looking for a specific abnormality, to monitor certain microbial imbalances, or to assess treatment efficacy. Thanks for sharing such detailed information. Great info! Organic acid testing (OAT) has become very popular amongst functional medicine doctors and dietitians. Click here to learn more about the how's and why's of testing your hormones. OAT is not able to detect intestinal parasites that might be contributing to your symptoms. What Does a Urine Organic Acids Test Evaluate? The Great Plains Laboratory, Inc.11813 West 77th StreetLenexa, KS 66214, The Great Plains Laboratory, Inc., 11813 West 77th Street, Lenexa, KS, 66214, United States, GPL-TOX Profile (Toxic Non-Metal Chemicals). Some of the nutritional markers tested as a part of OAT may point to valid nutrient deficiencies, mainly: methylmalonic acid, pantothenic acid, methylcitric acid, and uracil/thymine. The number of organic acids found in urine is enormous. When PAH isn’t working properly, the body tries to metabolize phenylalanine through an alternative pathway, and organic acids like phenyllactate and phenylacetate are produced as a result (6, 7). Watch this video for an overview of our Dried Urine Test for Comprehensive Hormones (DUTCH) Tutorial Series. Urinary organic acids typically tested that involve the mitochondria include: When these organic acids are out of balance, this clues the clinician to search for factors that may be impairing mitochondrial function. Metabolic reactions produce these compounds from the digestion of dietary protein, fat, and carbohydrates. Chromatography separates all of the different components found in the urine sample, while mass spectrometry is a tool used to identify and quantify each component by looking at its chemical makeup (132). We use the following tests: Amino Acids - Urine Test. Urinary levels of these organic acids can be impacted by things like genetic snps, nutrient deficiencies, diet, exposure to environmental toxins, stress, sleep, neuroendocrine tumors, supplements, and adrenal function (58, 59, 60, 61, 62, 63, 64). Learn more about OAT Easy to do with children and anyone who has a fear of needles whilst giving you a tremendous amount of information. OAT is relatively expensive and often isn’t covered by insurance, so it’s not a reasonable option for everyone. Metals Urine Test. Interpreting OAT results is very complicated, so it’s best to review your results with a health professional who has experience with OAT. If someone is only interested in looking at organic acids related to metabolism, the Metabolic Analysis Profile may be a good option. 3. Abnormally high levels of these microorganisms can cause or worsen behaviour disorders, hyperactivity, movement disorders, fatigue and immune function. This test has allowed me to investigate more deeply the chronic issues that contribute to female related conditions like PMS, uterine fibroids, endometriosis, chronic UTIs and vulvodynia. It gives clues if we have a blockage, nutritional insufficiencies, and/or bacterial overgrowth. These ketones can be detected in the urine with organic acid testing: Even when not in ketosis, high levels of other urinary organic acids can identify possible issues with carbohydrate metabolism. We use the following tests: Glyphosate - Urine Test. It is rarely used in isolation, and additional testing is usually ordered after looking at the results. Erica and Amy are experienced registered dietitians who are passionate about creating great nutrition content! Click here to get a PDF copy delivered to your inbox. Some factors that can influence organic acid production within the body include (2, 3): In order for the body to run effectively, it needs proper amounts of vitamins and minerals to act as cofactors for enzymatic reactions. The OAT test is an at home urine collection kit and is available in most states, and for international purchase. There are over 70 markers on the organic acids test including vitamins and antioxidants, oxidative stress, energy production, detoxification, neurotransmitter levels, oxalates, and intestinal yeast and bacteria. Coronavirus IgG Antibody $ 109.00. Thanks for sharing! AD(H)D Panel. Thus, organic acids in urine are often present at 100 times their concentration in the blood serum and thus are more readily detected in urine. In humans, organic acids are byproducts or intermediates of chemical reactions that occur within the body (1). It can reveal imbalances in metabolic pathways, nutritional imbalances, as well as abnormal microbial overgrowth in the small and large intestines. Keep reading to learn more about the science behind organic acid testing, who might benefit from it, and how to get tested. COMBO & TEST PANELS KITS (Some are Available in the USA only*) Autism Panel. Organic acid testing can also be used to detect deficiency (or insufficiency) of certain B vitamins. It is definitely a labor of love . Reason #4: Impaired Fatty Acid Metabolism, Reason #5: Ketosis or Poor Carbohydrate Metabolism. For healthcare practitioners interested in learning more about organic acid testing, Great Plains Laboratory regularly holds in-person trainings around the world. Many genetic disorders are caused by the production of an inefficient enzyme that reacts at a slower than usual rate, resulting in an accumulation of a metabolic intermediate. Importantly the OAT test also includes mitochondrial markers – associated with the Krebbs cycle and energy production (our ability to turn protein, fat and carbohydrate into energy). Want to save this article? Abnormally high levels of these microorganisms can cause or worsen behavior disorders, hyperactivity, … diagnostic of any particular overgrowth but can help guide further testing decisions. This urine-based test provides a wealth of information about the functioning of various bodily systems and can be used to identify possible nutrient deficiencies, gut dysbiosis, and more. The sample is then frozen and shipped to the laboratory, where organic acids are measured from the urine sample using liquid or gas chromatography-mass spectrometry (131). This site uses Akismet to reduce spam. Overall, organic acid testing can be a good starting point for complicated cases. This is such a helpful post! … The Organic Acid Test also known as the OAT test, specifically tests for organic acids – compounds in the urine that are produced during daily metabolism. from Great Plains Laboratory evaluates over 70 different organic acids. Your email address will not be published. They are not diagnostic of neurotransmitter levels in the brain or spinal cord. This video gives an overview of what we should see on the DUTCH Complete™ report. Organic acids are produced by bacteria in the gut as they metabolize various components of the foods we eat. It provides an accurate evaluation of intestinal yeast and bacteria. Quantity-+ Add to Cart Share Tweet Pin ... Organic Acids Test (OAT) - Nutritional & Metabolic Profile. Genetic diseases of the mitochondria, the cell’s energy source, as well as toxic chemicals that disrupt mitochondrial function cause elevation of succinic acid. 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